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林佳奇，教授、博士生导师。国家级青年人才、科技部青年科学家、大连市海外高层次人才。2012年在美国麻省理工学院材料科学与工程系任博士后研究员，2015年在美国麻省理工学院Koch 癌症研究中心Langer实验室任博士后研究员。2018年在BrainCo Inc.任职研发总监。主要从事于核酸药物、纳米生物界面、以及生物传感材料的研究工作。相关工作主要围绕mRNA药物的序列设计与递送、RNA药物的生产工艺与放大、生物大分子的胞内递送方法、以及柔性生物传感器的设计开发等方向。相关成果发表于Nature Biomedical Engineering，Nature Communications，ACS Nano，Nano Letters， Science Advance，Small等多个国际期刊，获得多个国内、国际专利。论文被引用次数超过2700+次，h-index=16。担任Biosensors客座编委。研究成果被Chemical Review、Chemical Society review、Accounts of Chemical research，Nature review drug discovery，Science Daily等期刊和媒体评述和报道。已授权专利4项，公开申请专利20余项。研究成果可应用于多种传染病的预防以及肿瘤、罕见病的治疗，其中针对带状疱疹和RSV的疫苗已经进入临床前阶段，已与多个具有疫苗生产资质的企业开展合作。在生物传感材料的转化方面取得突出成果，开发了半干水凝胶生物电极，解决了当前脑电/肌电采集信号质量差的问题，脑电产品受到了美国宇航局NASA的报道，肌电产品智能假肢被美国《时代》杂志评为2019年度100个最佳发明之一。

Selected publications:

1.Xingdi Cheng, Sujia Liu, Jing Sun, Lin Liu, Xinghuan Ma, Jingjiao Li, Bangda Fan, Chen Yang, Yuanyuan Zhao, Shuai Liu, Yixing Wen, Wei Li, Simin Sun, Shiwei Mi, Haonan Huo, Lei Miao, Hao Pan, Xiaolan Cui,* Jiaqi Lin,* and Xueguang Lu*.A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challeng.Advanced Materials.2023, 12, 2310886

2.Hailing Xue, Dongyang Wang, Mingyan Jin, Hanbing Gao, Xuhui Wang, Long Xia, Dong’ang Li, Kai Sun, Huanan Wang, Xufeng Dong, Chi Zhang, Fengyu Cong and Jiaqi Lin*. Hydrogel electrodes with conductive and substrate-adhesive layers for noninvasive long-term EEG acquisition. Microsystems & Nanoengineering. 2023, 9, 79

3. Miao, L.*; Lin, J.*(co-first); Huang, Y.; Li, L.; Delcassian, D.; Ge, Y.; Shi, Y.; Anderson, D. Synergistic Lipid Compositions for Albumin Receptor Mediated Delivery of mRNA to the Liver. Nature communications. 2020, 11, 2424

4. Lin, J.; Alexander-Katz, A. Cell Membranes Open “Doors” for Cationic Nanoparticles/Biomolecules: Insights into Uptake Kinetics. ACS Nano, 2013, 7, 10799-10808.

5. Lin, J.; Zhang, H.; Chen, Z.; Zheng, Y. Penetration of Lipid Membranes by Gold Nanoparticles: Insights into Cellular Uptake, Cytotoxicity and Their Relationship. ACS Nano, 2010, 4, 5421-5429.

6. Wang, D.; Lin, J.; Jia, F.; Shimkonis, J. C.; Nyoni, Z.; Lu, X. and Zhang, K. Bottlebrush-architechtured Poly(ethylene Glycol) as an Efficient Vector for RNA Interference in Vivo. Science Advance. 2019, 5, eaav9322

7. Lin, J.; Lei, M.; Zhong, G.; Lin, C.; Dargazangy, R.; Alexander-katz, A. Understanding the Synergistic Effect of Physicochemical Properties of Nanoparticles and their Cellular Entry Pathways. Communications Biology. 2020, 3, 205

8. Tang, Y.*; Wu, S.*; Lin, J.*(co-first); Cheng, L.; Zhou, J. Liao, G. and Li, C. Nanoparticles Targeted against Cryptococcal Pneumonia by Interactions between Chitosan and Its Peptide Ligand. Nano Letters 2018, 18, 6207-6213

9. Lin, J.; Dargazany, R.; Alexander-Katz, A. Lipid flip-flop and pore nucleation on zwitterionic bilayers are asymmetric under Ionic Imbalance. Small 2017, 13, 1603708

10. Lin, J.; Alexander-Katz, A. Probing Lipid Bilayer under Ionic Imbalance. Biophysical Journal. 2016, 111, 2460-2469.

欢迎对生物与医药、生物学、生物化工、纳米生物界面/生物屏障等研究方向有兴趣的博士后和同学加入课题组！

邮箱：jqlin@dlut.edu.cn

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