Release Time:2025-06-18  Hits:

Indexed by: Journal Papers

Date of Publication: 2021-04-09

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Volume: 60

Issue: 3

Page Number: 1561-1566

ISSN: 1433-7851

Key Words: allylic compounds; dienes; photocatalysis; radicals; titanium

Abstract: The addition of pi-allylmetal complexes to carbonyls is the most important route to homoallylic alcohols. This study reports the first photocatalytic generation of pi-allyltitanium complexes by a radical strategy. This novel strategy enables the three-component allylation of carbonyls with 1,3-butadiene, providing rapid access to valuable homoallylic alcohols (over 60 examples). The exceptional regio- and diastereoselectivity provided by dual photoredox/Ti catalysis is comparable to that of the Cr-catalyzed Nozaki-Hiyama-Kishi allylation reaction.