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论文类型：期刊论文

发表时间：2015-02-01

发表刊物：FOOD AND CHEMICAL TOXICOLOGY

收录刊物：SCIE、PubMed、Scopus

卷号：76

页面范围：70-76

ISSN号：0278-6915

关键字：Perfluorooctane sulfonate; Rat offspring; Hippocampus; Prenatal; Postnatal; Synaptic plasticity

摘要：The present study aims to explore the effects of perfluorooctane sulfonate (PFOS) on cognitive function in developing rats and the underlying mechanism associated with synaptic plasticity. Pregnant Wistar rats were fed with 0, 5, and 15 mg/L of PFOS via drinking water during gestation and lactation. Offspring were exposed to PFOS on prenatal and/or postnatal days by cross-fostering. Spatial learning and memory abilities were tested from postnatal day (PND) 35. We also analyzed the expression pattern of the synaptic plasticity-related genes and proteins in the hippocampus on PND7 and PND35. Results revealed that PFOS exposure reduced the spatial learning and memory abilities of the offspring, particularly of those with prenatal exposure. Meanwhile, protein levels of growth-associated protein-43, neural cell adhesion molecule 1, nerve growth factor, and brain-derived neurotrophic factor decreased on PND35, which are involved in the formation of synaptic plasticity. In contrast, significant increase in gap-43, ncarnl, and bdnf genes on the mRNA level was observed on PND7, possibly due to the post-transcriptional mechanism. Results of both behavioral effects and molecular endpoints suggested the high risk of prenatal PFOS exposure. The decline of spatial learning and memory abilities induced by developmental PFOS exposure was closely related to synaptic plasticity. (C) 2014 Elsevier Ltd. All rights reserved.