个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职:环境学院副院长
其他任职:环境学院教工党支部副书记
性别:女
毕业院校:大连理工大学
学位:博士
所在单位:环境学院
联系方式:Email:Liu_wei@dlut.edu.cn
电子邮箱:liu_wei@dlut.edu.cn
Human Nails Analysis as Biomarker of Exposure to Perfluoroalkyl Compounds
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论文类型:期刊论文
发表时间:2011-10-01
发表刊物:ENVIRONMENTAL SCIENCE & TECHNOLOGY
收录刊物:Scopus、SCIE、EI、PubMed、PKU、ISTIC
卷号:45
期号:19
页面范围:8144-8150
ISSN号:0013-936X
摘要:Extensive human exposure to perfluoroallcyl compounds (PFAA) together with their persistence and various toxicities have arisen increasing concern. A noninvasive method would improve exposure assessment for large population, especially the children susceptible to contaminants. The aim of the study was to assess the use of PFAA measurements in human nails as a biomarker of exposure to PFAAs. Fingernail, toenail, and blood samples were collected from 28 volunteers. The PFAA concentrations were determined by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Six PFAA were detected in nails, with perfluorooctane sulfonate (PFOS) being the compound with the highest median concentration (33.5 and 26.1 ng/g in fingernail and toenail, respectively). Followed was perfluorononanoate (PFNA), with the median concentrations of 20.4 and 16.8 ng/g, respectively, in fingernail and toenail. Other PFAA detected were perfluorooctanoate (PFOA), perfluorodecanoate (PFDA), perfluorododecanoate (PFDoA), and perfluorotetradecanoate (PFTA), with median levels ranging between 0.19 and 8.94 ng/g. PFOS and PFNA concentrations in fingernail significantly correlated with those in serum. Fingernail PFOS and PFNA levels were 2.8 and 24.4 times, respectively, higher than the serum levels. The accumulation of PFAA in nails, together with its advantages in noninvasive sampling and ability of reflecting long-term exposure, made nails PFAA an attractive biomarker of exposure.