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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化学学院
学科：有机化学
电子邮箱：liufengyu@dlut.edu.cn
A novel photocleaver with long wavelength absorption - Highly efficient antitumor agent: 4-(2-diethylamino-ethylamino)-8-oxo-8H-acenaphtho-[ 1,2-b] pyrrole-9-carbonitrile
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论文类型：期刊论文
发表时间：2005-07-01
发表刊物：CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
收录刊物：SCIE、ISTIC、CSCD
卷号：21
期号：4
页面范围：480-483
ISSN号：1005-9040
关键字：photocleaver; 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile; singlet oxygen; cytotoxicity
摘要：The photocleavage abilities of a novel family of compounds, 8-oxo-8H-acenaphtho[1, 2-b] pyrrole-9-carbonitrile and its derivatives(compounds 1-5) were evaluated with MI3 mp18 single strand circular DNA. Only compound 1 with a diethylamine group could bind to DNA via electrostatic attraction and intercalation. At a concentration of 50 mu mol/L, it could generate singlet oxygen to cleave circular DNA into linear DNA under the irradiation of long wavelength light(lambda > 400 nm). The antitumor ability of compound 1 was also evaluated in vitro, and its IC50 on HeLa cells was as low as 6.8 mu mol/L.