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论文类型：期刊论文

发表时间：2014-07-07

发表刊物：ANALYTICAL METHODS

收录刊物：SCIE、EI、Scopus

卷号：6

期号：13

页面范围：4661-4666

ISSN号：1759-9660

摘要：Electrochemiluminescence (ECL) of bimetallic ruthenium tris-bipyridyl complex [(bpy)(2)Ru(bpy)(CH2)(8)(bpy)Ru(bpy)(2)](4+) at a glassy carbon electrode has been employed for the determination of the four widely used quinolone antibiotics. The method gave a linear response from 1.0 x 10(-13) to 1.0 x 10(-6) mol L-1, 1.0 x 10(-14) to 1.0 x 10(-7) mol L-1, 1.0 x 10(-15) to 1.0 x 10(-6) mol L-1, and 1.0 x 10(-15) to 1.0 x 10(-6) mol L-1 concentration ranges for ofloxacin, levofloxacin, norfloxacin, and ciprofloxacin, respectively. Remarkable quantitation limits of 1.0 x 10(-13), 1.0 x 10(-14), 1.0 x 10(-15), and 1.0 x 10(-15) mol L-1 were observed for the detection of ofloxacin, levofloxacin, norfloxacin, and ciprofloxacin in phosphate buffer (0.10 mol L-1). These detection levels were much lower than those observed for other detection methods. The proposed method was successfully employed in the determination of ofloxacin, levofloxacin, norfloxacin, and ciprofloxacin after their addition into milk samples. Good reproducibility and stability were observed. This method allows for the development of an ECL-based method for the detection of quinolone antibiotic residues.