Release Time:2019-03-11  Hits:

Indexed by: Journal Article

Date of Publication: 2018-01-01

Journal: SYNTHESIS-STUTTGART

Included Journals: Scopus、EI、SCIE

Volume: 50

Issue: 2

Page Number: 341-348

ISSN: 0039-7881

Key Words: omega-substituted biuret; N-monosubstituted urea; potassium cyanate; dicyanic acid; selective reactions

Abstract: A novel, simple, and highly efficient method has been designed for the synthesis of -substituted arylbiurets in a one-pot reaction. The primary features of this protocol include readily available starting materials, an easy work-up procedure, and yields of 51 to 87%. omega-Substituted arylbiurets can be selectively prepared with an excess of potassium cyanate (KOCN). However, use of an excess of glacial acetic acid (AcOH) switches the reaction towards the formation of N-monosubstituted urea.