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Indexed by:期刊论文

Date of Publication:2016-06-08

Journal:TETRAHEDRON LETTERS

Included Journals:SCIE、Scopus

Volume:57

Issue:23

Page Number:2530-2532

ISSN No.:0040-4039

Key Words:2,4-Disubstituted pyrroles; Iododesilylation; Suzuki coupling reaction; TMS-migration

Abstract:In this study, we report a new strategy for the synthesis of 2,4-disubstituted pyrroles using a stepwise iododesilylation and palladium-catalysed Suzuki coupling reaction of 2,4-bis(trimethylsilyl)-1-t-Boc-1H-pyrrole (2). The regioselective iodo-desilylation followed by the Suzuki coupling reaction with concomitant Boc deprotection are critical aspects of the new synthesis method. (C) 2016 Elsevier Ltd. All rights reserved.