Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-06-08

Journal: TETRAHEDRON LETTERS

Included Journals: Scopus、SCIE

Volume: 57

Issue: 23

Page Number: 2530-2532

ISSN: 0040-4039

Key Words: 2,4-Disubstituted pyrroles; Iododesilylation; Suzuki coupling reaction; TMS-migration

Abstract: In this study, we report a new strategy for the synthesis of 2,4-disubstituted pyrroles using a stepwise iododesilylation and palladium-catalysed Suzuki coupling reaction of 2,4-bis(trimethylsilyl)-1-t-Boc-1H-pyrrole (2). The regioselective iodo-desilylation followed by the Suzuki coupling reaction with concomitant Boc deprotection are critical aspects of the new synthesis method. (C) 2016 Elsevier Ltd. All rights reserved.