大连理工大学主页平台管理系统刘云 Micro-capillary-based evanescent field biosensor for sensitive, label-free DNA detection 中文主页

论文成果

Micro-capillary-based evanescent field biosensor for sensitive, label-free DNA detection: 点击次数：; 发布时间： 2019-03-09; 发布时间：2019-03-09; 论文类型：期刊论文; 发表时间：2015-08-10; 发表刊物：OPTICS EXPRESS; 收录刊物：Scopus、EI、SCIE; 卷号：23; 期号：16; 页面范围：20686-20695; ISSN号：1094-4087; 摘要：We proposed and demonstrated a micro-capillary-based, high-sensitivity evanescent field biosensor for the cost-effective, rapid, and sensitive analysis and detection of specific DNA sequences. By functionalizing the surface of the tubing wall with ssDNA probe sequences, label-free DNA detection is achieved. The wavelength shift response of the surface-functionalized biosensors to DNA hybridization is monitored in real time. Our experiments show that the biosensor can operate at room temperature and is capable of performing label-free hybridization detection, analyte concentration measurement and nucleotide mismatch detection through a single sensing device. The sensor has many advantages, such as a simple manufacturing process, standardized production control, reliable quality, low cost and an economic demodulator. The compact nature and miniature size of the biosensing detection system makes it a good candidate for the rapid and highly sensitive detection of low-concentration analytes in micro-samples for cost-effective, real-time, and on-site analysis in the fields of life science, pharmaceutical chemistry, medical science and criminal investigation. (C) 2015 Optical Society of America

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刘云

个人学术主页

副教授博士生导师硕士生导师

性别：男

毕业院校：大连理工大学

学位：博士

所在单位：物理学院

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