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论文类型：期刊论文

发表时间：2018-08-01

发表刊物：MICROFLUIDICS AND NANOFLUIDICS

收录刊物：SCIE

卷号：22

期号：8

ISSN号：1613-4982

关键字：Dynamic biochemical signals; Microfluidics; Transmission characteristics; Nonlinear modulation; Low-pass filtering

摘要：A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the transmission characteristics of dynamic biochemical signals in pulsatile flows by analytically solving the convection-diffusion equation for the time-dependent Taylor-Aris dispersion with perturbation method. We prove that the transmission of dynamic biochemical signals in pulsatile flows is subject to the two correlate effects: low-pass filtering and nonlinear amplitude-frequency modulation. These two effects are systematically characterized and the influence factors are studied, including the biochemical signal frequency, the pulsatile flow frequency, the transmission distance and the average pulsatile flow rate. We concluded that the balance of multiple factors should be taken into account for better loading biochemical signals on cells cultured in the microfluidic channel.