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论文类型：期刊论文

发表时间：2012-02-15

发表刊物：BIOSENSORS & BIOELECTRONICS

收录刊物：SCIE、EI、PubMed

卷号：32

期号：1

页面范围：293-296

ISSN号：0956-5663

关键字：Graphene nanoribbon; High selectivity; Cysteine; Electrochemical method

摘要：Selective detection of cysteine in serum samples was achieved on a graphene nanoribbon (GNR) and Nafion nanocomposite modified electrode with high precision. The superior conductivity and abundant amount of active chemical oxygen groups on the edge of GNR led to extremely highly electrocatalytic activity of GNR towards the electrochemical oxidation of cysteine at +0.025 V. The electrocatalytic behavior was further used for sensitive detection of cysteine by differential pulse voltammetry. Under optimized conditions, the calibration curve was linear in the range from 25 nM to 500 mu M. The electrochemical sensor showed strong antifouling ability, good stability and selectivity. It could effectively exclude the interferences from other kinds of biothiols and the biological relevant species, thus had great perspective for in vivo analysis of biological samples. (C) 2011 Elsevier B.V. All rights reserved.