孟长功

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:男

毕业院校:中科院金属所

学位:博士

所在单位:化工学院

学科:无机化学

办公地点:大连理工大学化学楼401

联系方式:13940825088

电子邮箱:cgmeng@dlut.edu.cn

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A smart multifunctional nanocomposite for intracellular targeted drug delivery and self-release

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论文类型:期刊论文

发表时间:2011-10-14

发表刊物:NANOTECHNOLOGY

收录刊物:Scopus、SCIE、EI、PubMed

卷号:22

期号:41

页面范围:415101

ISSN号:0957-4484

摘要:A multifunctional 'all-in-one' nanocomposite is fabricated using a colloid, template and surface-modification method. This material encompasses magnetic induced target delivery, cell uptake promotion and controlled drug release in one system. The nanocomposite is characterized by scanning electron microscopy, transmission electron microscopy, x-ray diffraction, N(2) adsorption and vibrating sample magnetometry. The prepared material has a diameter of 350-400 nm, a high surface area of 420.29 m(2) g(-1), a pore size of 1.91 nm and a saturation magnetization of 32 emu g(-1). Doxorubicin (DOX) is loaded in mesopores and acid-sensitive blockers are introduced onto the orifices of the mesopores by a Schiff base linker to implement pH-dependent self-release. Folate was also introduced to improve DOX targeted delivery and endocytosis. The linkers remained intact to block pores with ferrocene valves and inhibit the diffusion of DOX at neutral pH. However, in lysosomes of cancer cells, which have a weak acidic pH, hydrolysis of the Schiff base group removes the nanovalves and allows the trapped DOX to be released. These processes are demonstrated by UV-visible absorption spectra, confocal fluorescence microscopy images and methyl thiazolyl tetrazolium assays in vitro, which suggest that the smart nanocomposite successfully integrates targeted drug delivery with internal stimulus induced self-release and is a potentially useful material for nanobiomedicine.