Tailored Robust Hydrogel Composite Membranes for Continuous Protein Crystallization with Ultrahigh Morphology Selectivity
发表时间：2019-11-07
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- 论文类型：
- 期刊论文
- 第一作者：
- Wang, Lin
- 通讯作者：
- Jiang, XB (reprint author), Dalian Univ Technol, Engn Lab Petrochem Energy Efficient Separat Techn, Sch Chem Engn, State Key Lab Fine Chem, Dalian 116024, Liaoning, Peoples R China.
- 合写作者：
- He, Gaohong,Ruan, Xuehua,Zhang, Daishuang,Xiao, Wu,Li, Xiangcun,Wu, Xuemei,Jiang, Xiaobin
- 发表时间：
- 2018-08-08
- 发表刊物：
- ACS APPLIED MATERIALS & INTERFACES
- 收录刊物：
- PubMed、SCIE
- 文献类型：
- J
- 卷号：
- 10
- 期号：
- 31
- 页面范围：
- 26653-26661
- ISSN号：
- 1944-8244
- 关键字：
- hydrogel composite membrane; continuous protein crystallization; morphology selectivity; nucleation and growth control; lysozyme
- 摘要：
- The tailored and robust hydrogel composite membranes (HCMs) with diverse ion adsorption and interfacial nucleation property are prepared and successfully used in the continuous lysozyme crystallization. Beyond the heterogeneous supporter, the HCMs functioning as an interface ion concentration controller and nucleation generator are demonstrated. By constructing accurately controlled nucleation and growth circumstances in the HCM-equipped membrane crystallizer, the target desired morphology (hexagon cube) and brand-new morphology (multiple flower shape) that differ from the ones created in the conventional crystallizer are continuously and repetitively generated with ultrahigh morphology selectivity. These tailored robust HCMs show great potential for improving current approaches to continuous protein crystallization with specific crystal targets from laboratorial research to actual engineering applications.
- 是否译文：
- 否
