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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
Asymmetric alpha-Hydroxylation of beta-Indanone Esters and beta-Indanone Amides Catalyzed by C-2 ' Substituted Cinchona Alkaloid Derivatives
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论文类型：期刊论文
发表时间：2016-03-03
发表刊物：ADVANCED SYNTHESIS & CATALYSIS
收录刊物：SCIE
卷号：358
期号：5
页面范围：737-745
ISSN号：1615-4150
关键字：Cinchona alkaloid derivatives; enantioselectivity; alpha-hydroxylation; organocatalysis; synthetic methods
摘要：The highly catalytic asymmetric alpha-hydroxylation of b-indanone esters and b-indanone amides using peroxide as the oxidant was realized with a new C-2' substituted Cinchona alkaloid derivatives. The two enantiomers of alpha-hydroxy-beta-indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the cor-responding alpha-hydroxy-beta-indanone esters and a-hydroxy- b-indanone amides with up to 99% yield and 98% ee.