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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
Visible Light-Induced Aerobic Epoxidation of alpha,beta-Unsaturated Ketones Mediated by Amidines
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论文类型：期刊论文
发表时间：2021-01-30
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
卷号：83
期号：21
页面范围：13051-13062
ISSN号：0022-3263
关键字：Density functional theory; Ketones; Light, Aerobic epoxidation; Flow synthesis; Photoepoxidation; Singlet oxygen; Tetramethylguanidine; Unsaturated ketones; Visible light; Visible light induced, Molecular oxygen, amidine; chalcone; guanidine derivative; ketone derivative; oxygen; photosensitizing agent; porphyrin derivative; singlet oxygen, aerobic metabolism; Article; chemical structure; density functional theory; epoxidation; light; photooxidation; proton nuclear magnetic resonance; reaction analysis; reaction optimization; screening; synthesis
摘要：An aerobic photoepoxidation of alpha,beta-unsaturated ketones driven by visible light in the presence of tetramethylguanidine (3b), tetraphenylporphine (H2TPP), and molecular oxygen under mild conditions was revealed. The corresponding alpha,beta-epoxy ketones were obtained in yields of up to 94% in 96 h. The reaction time was shortened to 4.6 h by flow synthesis. The mechanism related to singlet oxygen was supported by experiments and density functional theory (DFT) calculations.