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论文类型：期刊论文

发表时间：2022-06-30

发表刊物：化工进展

所属单位：化工学院

期号：z2

页面范围：407-414

ISSN号：1000-6613

摘要：In this paper,we adopt the technology of patent CN 102863437 A,use Aspen Batch Process Developer modeling and simulation system, design batch process. The inherent advantages of batch processes,including their ability to produce multiple related products in the same facility,as well as their ability to handle variations in feed stocks,product specifications and market demand patterns,makes them well suited for the manufacture of low-volume,high-value products.For these reasons,batch processes are the production scheme of choice for the pharmaceutical, biotechnology, specialty chemical, consumer products and agricultural chemical industries.The production of these high value-added gyon chemicals, as opposed to bulk,commodity chemicals,today contributes a significant and growing portion of the revenue and earnings of the chemical process industries.Over the last four decades,the use of computer-based modeling and simulation tools to support process development and design has become routine in the continuous chemical industry.However, this is still not the case in the batch process industry.The main reason for this has been the unavailability of such tools for batch processes until recently.A number of these tools are available today, including BATCHES, gPROMS and Aspen Batch Process Developer.This paper describes the use of Aspen Batch Process Developer modeling and simulation system in preliminary design and optimization of production plant process of 25 tons of lurasidone hydrochloride.The production process is divided into six modules,sulfonation,ammonolysis,hydrogenation,synthesis,salify and purify.The overall design and optimization implement quality from design concept.

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