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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
Methylhydrazine-induced enantioselective alpha-hydroxylation of beta-keto esters with molecular oxygen catalyzed by hydroquinine
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论文类型：期刊论文
发表时间：2015-01-07
发表刊物：TETRAHEDRON
收录刊物：SCIE、Scopus
卷号：71
期号：1
页面范围：85-90
ISSN号：0040-4020
关键字：Methylhydrazine; beta-Keto esters; Cinchona-alkaloid; Molecular oxygen; Organocatalysis
摘要：Methylhydrazine-induced alpha-hydroxylation of beta-dicarbonyl compounds was achieved using O-2 as the oxygen source. This reaction provides an efficient approach to enantioenriched alpha-hydroxy beta-dicarbonyl compounds, which are valuable substances and widely used in the chemical and pharmaceutical industry. A wide variety of beta-keto esters could undergo this oxidation to give the corresponding products in excellent yields (up to 95%) and with good enantioselectivities (up to 85% ee). The mild reaction conditions and the use of molecular oxygen as oxidant make this protocol very environmentally friendly and practical. (C) 2014 Elsevier Ltd. All rights reserved.