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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
Enantioselective alpha-hydroxylation of beta-keto esters catalyzed by chiral S-timolol derivatives
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论文类型：期刊论文
发表时间：2012-09-23
发表刊物：TETRAHEDRON
收录刊物：SCIE、Scopus
卷号：68
期号：38
页面范围：7973-7977
ISSN号：0040-4020
关键字：Chiral drug; Aryloxy aminopropanol organocatalyst; beta-Keto ester; Asymmetric alpha-hydroxylation
摘要：A screen of aryloxy aminopropanol organocatalysts derived from the beta-blocker inhibitor S-timolol determined the most active catalyst of asymmetric alpha-hydroxylation of beta-keto esters. (R)-1-(tert-butylamino)-3-(3,4,5-trimethoxyphenoxy) propan-2-ol (3k) was the most effective derivative, enantioselectively catalyzing alpha-hydroxylation of beta-keto esters using tert-butyl hydroperoxide as the oxidant in hexane to afford the corresponding products in excellent yield and with good enantioselectivity (up to 96% yield, 88% ee). (C) 2012 Elsevier Ltd. All rights reserved.