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论文类型：期刊论文

发表时间：2011-11-01

发表刊物：MEDICINAL CHEMISTRY RESEARCH

收录刊物：Scopus、SCIE

卷号：20

期号：8

页面范围：1154-1157

ISSN号：1054-2523

关键字：Cinepazide; Vasodilator; Cis-trans isomerism; Photoisomerism

摘要：The photoinduced tautomerisation of cinepazide maleate (1), an effective vasodilator widely used in clinical therapy, had been investigated. It was found that (i) the higher the concentration of cinepazide maleate (1), the more stable it was; (ii) the effect of light on the photoisomerism of cinepazide maleate (1) was obvious in a suitable wavelength (e.g., 365 nm); (iii) solvents (e.g., acetone) with carbonyl chromophore absorbing UV could inhibit the generation of cis-isomer; (iv) anthranilic acid could be used as an effective ultraviolet absorbent and (v) the cinepazide maleate (1) could be properly stored under the airtight, light-free and room temperature conditions.