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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：大连理工大学
学位：硕士
所在单位：化工学院
学科：药物工程. 精细化工. 药物化学
办公地点：大连理工大学西部校区化工实验楼G段311
联系方式：mengqw@dlut.edu.cn
电子邮箱：mengqw@dlut.edu.cn
扫描关注
Lappaconitine-Catalyzed Asymmetric alpha-Hydroxylation of beta-Keto Esters: A Bronsted Base Organocatalyst Developed from Terpenoid Alkaloids
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论文类型：期刊论文
发表时间：2009-10-01
发表刊物：SYNLETT
收录刊物：SCIE、Scopus
期号：16
页面范围：2659-2662
ISSN号：0936-5214
关键字：lappaconitine; asymmetric alpha-hydroxylation; beta-keto esters; organocatalyst; terpenoid alkaloid
摘要：Discovering organocatalysts with novel framework from terpenoid alkaloids is presented in this paper. Lappaconitine was found to enantioselectively catalyze alpha-hydroxylation of beta-keto esters using tert-butyl hydroperoxide as the oxidant in chloroform to afford the corresponding products in high yields and good enantioselectivity (up to 85% ee).