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论文类型：期刊论文
发表时间：2014-03-01
发表刊物：JOURNAL OF SURFACTANTS AND DETERGENTS
收录刊物：SCIE、EI、Scopus
卷号：17
期号：2
页面范围：261-268
ISSN号：1097-3958
关键字：Synthesis; Thio galactose; Cationic lipids; Vesicle
摘要：Two double chain cationic lipids QAS C (n) -2-S (n = 12, 14) derived from thio galactose and carbamate-linkage tertiary amine were synthesized and their structures were confirmed by MS, TOF-MS, H-1 NMR and C-13 NMR. The QAS C-12-2-S revealed superior surface activity compared with QAS C-14-2-S with lower CMC and gamma(CMC). Though Lipo C-12-2-S displayed large average particle-size with high polydispersity, positive charged Lipo C (n) -2-S can be combined with the negative charged DNA, also negatively stained TEM images confirmed the formation of vesicles. All the above prove that the Lipo C (n) -2-S is helpful for gene transfection.