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论文类型：期刊论文
发表时间：2008-04-01
发表刊物：CHEMICAL BIOLOGY & DRUG DESIGN
收录刊物：SCIE
卷号：71
期号：4
页面范围：336-344
ISSN号：1747-0277
关键字：cationic lipids; gene delivery; glycerol backbone based; transfection efficiency
摘要：Transfection activities of two series of synthetic glycerol backbone-based cationic lipids were studied as gene delivery carriers. The variable length of hydrocarbon chains, diverse quaternary ammonium heads, different linkage, as well as alternative anion combined with them allowed to find how these factors affect cationic lipids on their gene delivery performance. The structure-function relationship of the synthetic glycerol backbone-based cationic lipids was discussed, and the transfection efficiency of some of the cationic liposomes was superior or parallel to that of two commercial transfection agents.