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论文类型：期刊论文
发表时间：2008-01-15
发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY
收录刊物：SCIE
卷号：16
期号：2
页面范围：995-1005
ISSN号：0968-0896
关键字：carbamate-linked; cationic lipids; transfection; gene delivery
摘要：Series of cationic lipids 1a-p, with variable length of hydrocarbon chains, alternative quaternary ammonium heads, carbamate linkages between hydrocarbon chains and quaternary ammonium heads, as well as different anion combined with them, were synthesized for liposome-mediated gene delivery. Two plasmid DNAs, pGL3-control and pGFP-N2, were transferred by cationic liposomes formed from the above cationic lipids into five mammalian cell lines, and the transfection efficiency of some of the cationic liposomes was superior or parallel to that of two commercial transfection agents, Lipofectamine2000 (TM) and Sofast (TM). (C) 2007 Elsevier Ltd. All rights reserved.