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论文类型：期刊论文

发表时间：2018-01-01

发表刊物：Materials science & engineering. C, Materials for biological applications

收录刊物：PubMed、SCIE、EI

卷号：87

页面范围：90-103

ISSN号：1873-0191

关键字：Micro-arc oxidation; Micro/nano dual-scale structure; TiO2 coating; Crocompatibility; Osseointegration

摘要：A novel "cortex-like" micro/nano dual-scale structured TiO2 coating was prepared on a titanium surface by micro-arc oxidation (MAO) with tetraborate electrolytes. This structure, which combines microslots with nanopores, exhibits super hydrophilicity. This coating modified the surface structure, chemistry, and hydrophilicity in a one-step treatment. Evolution of the coating together with its surface and structure properties was studied. We propose a forming mechanism of the dual-scale structure in which the oxides formed during the MAO discharge dissolve in the tetraborate electrolytes, leaving little or no deposition outside the discharge channels. We performed in vitro tests using human bone marrow-derived mesenchymal stem cells (hBMSCs) that compared this coating with a "volcano-like" MAO coating and a commercial sandblasted, large-grit and acid-etched (SLA) coating. The adhesion, morphology, proliferation, and differentiation of hBMSCs, together with the matrix mineralization, were investigated. Results suggest that the "cortex-like" structure significantly promotes the adhesion, spreading, and differentiation of cells and increases the matrix mineralization. In vivo tests with mongrel dogs showed an excellent osseointegration of the "cortex-like" coating. The combination of the dual-scale structure and the hydrophilicity of the "cortex-like" TiO2 coating synergistically resulted in an outstanding cytocompatibility and osseointegration, which may facilitate a higher level of implant success. Copyright © 2018 Elsevier B.V. All rights reserved.