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发表时间：2012-01-01

发表刊物：Chinese Journal of Tissue Engineering Research

卷号：16

期号：38

页面范围：7092-7095

ISSN号：2095-4344

CN号：21-1581/R

摘要：BACKGROUND: The effective ways to improve the success rate of titanium implants are to improve the antibacterial properties of titanium implants and reduce the incidence of peri-implantitis. OBJECTIVE: To investigate the antibacterial properties of the zinc-containing hydroxyapatite (ZnHA)/titania (TiO2) hybrid coating. METHODS: First, a porous titania coating was produced on pure titanium (Ti) by micro-arc oxidation treatment. And then a ZnHA /TiO_2 biological coating was prepared via sol-gel method. The concentration of Zn~(2+) release of Ti samples in each group was measured by inductively coupled plasma emission spectrometer. The adhesion number and morphologies of Porphyromonas gingivalis W83 implanted on the surface of hybrid coating were characterized by scanning electron microscope and bacteriostasis experiment. RESULTS AND CONCLUSION: The concentration of Zn~(2+) release in the Tris buffer was increased with the Zn/Ca molar ratio in precursor solution increased. The growth of Porphyromonas gingivalis on the surface of ZnHA/TiO_2 coating was inhibited obviously, and the form of Porphyromonas gingivalis adhered on the surface of coating had changed. These findings suggest that the ZnHA/TiO_2 hybrid coatings on titanium implants have good antibacterial property.

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