谢晴

Senior Engineer  

Gender:Female

Alma Mater:大连理工大学

Degree:Doctoral Degree

School/Department:环境学院

Discipline:Environmental Engineering

Business Address:环境楼A315

E-Mail:qingxie@dlut.edu.cn


Paper Publications

Distinct Photolytic Mechanisms and Products for Different Dissociation Species of Ciprofloxacin

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Indexed by:期刊论文

Date of Publication:2013-05-07

Journal:ENVIRONMENTAL SCIENCE & TECHNOLOGY

Included Journals:SCIE、EI、PubMed、PKU、ISTIC、Scopus

Volume:47

Issue:9

Page Number:4284-4290

ISSN No.:0013-936X

Abstract:As many antibiotics are ionizable and may have different dissociation forms in the aquatic environment, we hypothesized that the different dissociation species have disparate photolytic pathways, products, and kinetics, and adopted ciprofloxacin (CIP) as a case to test this hypothesis. Simulated sunlight experiments and matrix calculations were performed to differentiate the photolytic reactivity for each dissociation species (H4CIP3+, H3CIP2+, H2CIP+, HCIP0, and CIP-). The results prove that the five dissociation species do have dissimilar photolytic kinetics and products. H4CIP3+ mainly undergoes stepwise cleavage of the piperazine ring, while H2CIP+ mainly undergoes defluorination. For H3CIP2+, HCIP, and CIP, the major photolytic pathway is oxidation. By density functional theory calculation, we clarified the defluorination mechanisms for the five dissociation species at the excited triplet states: All the five species can defluorinate by reaction with hydroxide ions (OH-) to form hydroxylated products, and H2CIP+ can also undergo C-F bond cleavage to produce F- and a carbon-centered radical. This study is a first attempt to differentiate the photolytic products and mechanisms for different dissociation species of ionizable compounds. The results imply that for accurate ecological risk assessment of ionizable emerging pollutants, it is necessary to investigate the environmental photochemical behavior of all dissociation species.

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