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Date of Publication:2015-01-01

Journal:应用与环境生物学报

Volume:21

Issue:6

Page Number:981-986

ISSN No.:1006-687X

Abstract:Synt hetic microbial community represents an emerging frontier of
   synthetic biology at the level of microbial community and their
   applications have recently gained a lot of interest worldwide. This
   study reviews the characteristics, interspecies interactions, microbial
   regulations, and applications of synthetic microbial communities in
   bioengineering. Synthetic microbial communities, composed of multiple
   species with well-defi ned genetic background, can accomplish specifi c
   functions through interactions among microorganisms. These syn thetic
   communities are characterized with low complexity, high controllability
   and stability. Various interactions may exist in synthetic microbial
   communities, including mutualism(cooperation), commensalism, parasitism
   or predation, and competition. These interactions can be regulated by
   modifying the cell-cell communication, metabolic pathway and spatial
   structures, thus achieving engineering of synthetic communities. In the
   last few years, synthetic microbial communities have b een widely used i
   n the fi eld of bioprocessing, focusing on fuel production, synthesis of
   high-value chemicals, and pollutants bioremediation. However, the
   interactions in synthetic microbial communities have not been fully
   parsed yet, leaving limited capacity for simultaneous regulating the
   composition and function of the communities. Therefore, it should be the
   focus of future research to combine the synthetic biology, systematic
   biology and bioinformatics to rationally design and fabricate stable and
   efficient synthetic microbial communities, as well as to optimize and
   regulate the bioprocesses.

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