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论文类型：期刊论文

发表时间：2021-04-12

发表刊物：BIOMATERIALS

卷号：233

页面范围：119755

ISSN号：0142-9612

关键字：tumor hypoxia; Chemo-PDT; Catalase; Immunosuppressive TME; Folate receptor targeting

摘要：Photodynamic therapy (PDT) and chemotherapy has been applied as a prospective approach in tumor therapeutics. However, suffering from the inherent hypoxia status in tumor microenvironment (TME), the anticancer efficiency is enormously restricted, especially PDT. Herein, we develop a unique liposomal encapsulated catalase (CAT), lyso-targeted NIR photosensitizer (MBDP) and doxorubicin (Dox), forming FA-L@MD@CAT, to increase tumor oxygenation by catalyzing intratumoral high-expressed H2O2 for enhancing the combination of chemoPDT. Moreover, the enhanced tumoral oxygenation not only facilitates singlet oxygen (O-1(2)) production but also reverses immunosuppressive TME by modulating immune cytokines to favor antitumor immunities, which significantly induce tumor death. Notably, this system also realizes specific tumor recognition to folate receptor upregulated tumors and improves intratumoral accumulation. This work provides an effective strategy to promote tumor therapeutic index, which may possess a promising future in clinical application.