大连理工大学主页平台管理系统宋慧 Joint modeling of longitudinal proportional measurements and survival time with a cure fraction 中文主页

论文成果

Joint modeling of longitudinal proportional measurements and survival time with a cure fraction: 点击次数：; 发布时间： 2019-03-12; 发布时间：2019-03-12; 论文类型：期刊论文; 发表时间：2016-12-01; 发表刊物：SCIENCE CHINA-MATHEMATICS; 收录刊物：Scopus、SCIE; 卷号：59; 期号：12,SI; 页面范围：2427-2442; ISSN号：1674-7283; 关键字：cure fraction; joint model; Laplace approximation; proportional data; simplex distribution; survival times; 摘要：In cancer clinical trials and other medical studies, both longitudinal measurements and data on a time to an event (survival time) are often collected from the same patients. Joint analyses of these data would improve the efficiency of the statistical inferences. We propose a new joint model for the longitudinal proportional measurements which are restricted in a finite interval and survival times with a potential cure fraction. A penalized joint likelihood is derived based on the Laplace approximation and a semiparametric procedure based on this likelihood is developed to estimate the parameters in the joint model. A simulation study is performed to evaluate the statistical properties of the proposed procedures. The proposed model is applied to data from a clinical trial on early breast cancer.

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讲师硕士生导师

性别：女

毕业院校：Queen's University(Canada)

学位：博士

所在单位：数学科学学院

学科：概率论与数理统计

办公地点：数学楼207

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