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论文类型：期刊论文

发表时间：2013-08-01

发表刊物：Physiological reports

收录刊物：PubMed

卷号：1

期号：3

页面范围：e00053

ISSN号：2051-817X

关键字：Amplitude of the first heart sound,exponential model,model fitting,rise rate of left ventricular pressure

摘要：The relationships between the amplitude of the first heart sound (S1) and the rising rate of left ventricular pressure (LVP) concluded in previous studies were not consistent. Some researchers believed the relationship was positively linear; others stated the relationship was only positively correlated. To further investigate this relationship, this study simultaneously sampled the external phonocardiogram, electrocardiogram, and intracardiac pressure in the left ventricle in three anesthetized dogs, while invoking wide hemodynamic changes using various doses of epinephrine. The relationship between the maximum amplitude of S1 and the maximum rising rate of LVP and the relationship between the amplitude of dominant peaks/valleys and the corresponding rising rate of LVP were examined by linear, quadratic, cubic, and exponential models. The results showed that the relationships are best fit by nonlinear exponential models.