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Indexed by:期刊论文

Date of Publication:2013-09-01

Journal:INTERNATIONAL JOURNAL OF BIOMATHEMATICS

Included Journals:SCIE、Scopus

Volume:6

Issue:5

ISSN No.:1793-5245

Key Words:Nonlinear hybrid dynamical system; biological robustness; system identification 3-HPA; inhibition range

Abstract:As an important intermediate substance in the process of producing 1, 3-propanediol (1, 3-PD) by bio-dissimilation of glycerol, the concentration of 3-hydroxypropionaldehyde (3-HPA) has inhibitory action on glycerol dehydratase (GDHt) and 1, 3-propanediol oxidoreductase (PDOR). Considering the transmission of glycerol and 1, 3-PD across cell membrane by both passive diffusion and active transmission as well as the inhibitory action of 3-HPA on the specific rate of growth, this paper aims to establish and discuss a nonlinear hybrid dynamical system model to ascertain the concentration range of 3-HPA where it does exhibit an inhibitory action on GDHt and PDOR. A quantitative definition of biological robustness is presented and an identification model is established based on biological robustness. An algorithm procedure is constructed to solve the identification problem. Numerical results show that only within a proper concentration range 3-HPA can have inhibitory action on the two enzymes mentioned above.