Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2009-11-01

Journal: NONLINEAR ANALYSIS-HYBRID SYSTEMS

Included Journals: Scopus、EI、SCIE

Volume: 3

Issue: 4

Page Number: 455-462

ISSN: 1751-570X

Key Words: Batch culture; Specific rate of cell growth; Nonlinear dynamical system; Parameters identification

Abstract: The bioconversion of glycerol to 1,3-propanediol is a complex bioprocess. In this study, we aim to explore a novel model for describing the multistage cell growth in batch culture. This is achieved by a modification at the specific rate of cell growth in consideratior of its time-dependent changes. The existence, uniqueness and boundedness of solutions to the system and the continuity of solutions with respect to the parameters are discussed. In addition, a parameter identification problem of the system is developed and a feasible optimization algorithm is constructed to solve it. Numerical result shows that the improved model could describe the batch culture well. (C) 2009 Elsevier Ltd. All rights reserved.