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论文类型：期刊论文

发表时间：2013-04-01

发表刊物：BIOPROCESS AND BIOSYSTEMS ENGINEERING

收录刊物：SCIE、EI、PubMed

卷号：36

期号：4

页面范围：433-441

ISSN号：1615-7591

关键字：Complex metabolic network; Biological robustness; System identification; Transport mechanism; Optimal algorithm

摘要：Understanding the transport mechanism of 1,3-propanediol (1,3-PD) is of critical importance to do further research on gene regulation. Due to the lack of intracellular information, on the basis of enzyme-catalytic system, using biological robustness as performance index, we present a system identification model to infer the most possible transport mechanism of 1,3-PD, in which the performance index consists of the relative error of the extracellular substance concentrations and biological robustness of the intracellular substance concentrations. We will not use a Boolean framework but prefer a model description based on ordinary differential equations. Among other advantages, this also facilitates the robustness analysis, which is the main goal of this paper. An algorithm is constructed to seek the solution of the identification model. Numerical results show that the most possible transport way is active transport coupled with passive diffusion.