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论文类型：期刊论文

发表时间：2009-11-01

发表刊物：NONLINEAR ANALYSIS-HYBRID SYSTEMS

收录刊物：SCIE、EI、Scopus

卷号：3

期号：4

页面范围：455-462

ISSN号：1751-570X

关键字：Batch culture; Specific rate of cell growth; Nonlinear dynamical system; Parameters identification

摘要：The bioconversion of glycerol to 1,3-propanediol is a complex bioprocess. In this study, we aim to explore a novel model for describing the multistage cell growth in batch culture. This is achieved by a modification at the specific rate of cell growth in consideratior of its time-dependent changes. The existence, uniqueness and boundedness of solutions to the system and the continuity of solutions with respect to the parameters are discussed. In addition, a parameter identification problem of the system is developed and a feasible optimization algorithm is constructed to solve it. Numerical result shows that the improved model could describe the batch culture well. (C) 2009 Elsevier Ltd. All rights reserved.