王天禄，博士，主任医师，博士生导师，香港大学访问学者，辽宁省肿瘤医院胸部放疗科主任。从事临床工作20余年，擅长肺癌、鼻咽癌、直肠癌、食管癌、肝癌、乳腺癌、脑肿瘤、头颈癌、恶性淋巴瘤等恶性肿瘤的临床治疗，多年从事一线临床及教学科研工作。以纳米机器人肿瘤检测与治疗、智能医疗可穿戴设备、人工智能在医学上的应用为主要科研方向，进行肿瘤基础及临床转化研究。以第一/通讯作者（包括共同通讯）在Molecular Cancer（中科院1区，IF：37.3）、TrAC （中科院1区，分析化学TOP1期刊，IF：14.9）、Journal of Pharmaceutical Analysis（中科院1区，药物分析TOP1期刊，IF：14.0）等期刊发表高水平SCI论文28篇，国内核心期刊论文10余篇，累计影响因子158分，授权专利发明43项（第一发明人），签署转化协议1项（500万），5项专利实现技术成果转让（10万），主持国家科技部、教育部、国家癌症中心及省部级课题12项，沈阳市重大科技创新研发计划项目1项，肿瘤质谱中心项目1项，主持开展临床新技术项目7项，2017年和2018年分别获得辽宁省自然科学学术成果奖。名下研究生8人次获得一等奖学金、优秀研究生，9人次获得国家奖学金，1人次获辽宁省优秀毕业生，1人次获得研究生科技创新基金，带领本科生获国家级大学生创新创业项目1项，“红医杯”银奖3项。

研究方向：胸部肿瘤综合治疗、免疫与靶向治疗、纳米机器人技术、人工智能医学应用、肿瘤转化研究。

学术兼职：

辽宁省生命科学学会肿瘤放射免疫治疗分会                        主任委员

辽宁省医学会放射肿瘤治疗学分会                                            副主任委员

辽宁省细胞生物学学会肿瘤智能医疗专委会                         副主任委员

民盟沈阳市医药卫生工作委员会                                                 副主任委员

辽宁省基层卫生协会头颈肿瘤专业委员会                            常务委员

世界华人肿瘤医师协会肺癌工作委员会                                        委员

中国肿瘤放射治疗联盟放射免疫工作委员会                          常委

中国中药协会粘膜修复药物研究专业委员会                         委员

辽宁省营养学会肿瘤营养治疗委员会                                        委员

中国抗癌协会肿瘤整合支持治疗治疗委员会                             委员

育人愿景：课题组通过“医工产学研”平台，医工交叉融合推动医疗技术的不断创新，进行肿瘤基础及临床转化研究，致力于培养具有工科与医学学科交叉背景的创新性复合型人才，联系方式：wangtianlu@dlut.edu.cn。

科研项目:

（1）国家科技部，建立肺癌个体化放射和免疫联合治疗多中心临床试验平台，G2023127016L，主持；

（2）教育部，基于免疫生物标记物IDO1建立肺癌放射和免疫联合治疗创新临床试验平台，202311060014，主持；

（3）医工交叉基金，面向肺癌围手术期康复监测的智能可穿戴电化学传感器研发，主持；

（4）教育部，放射性口腔黏膜炎生理盐水对比液体伤口敷料的随机、平行对照试验，2024GR072，主持；

          （5）卫健委，面向基层卫生人才肿瘤防治核心知识及技能培训订单式服务及运行机制研究，No.2024-N008-02 ，主持

（6）基于纳米机器人原代癌细胞机械特性检测方法和预后模型研究，2019-KF-01-01，主持；

（7）外泌体物理特性信息检测及其在肺腺癌免疫治疗反应预测中的应用和机理研究，2020-ZLLH-47，主持；

（8）基于质谱检测分析联合大数据采用人工智能的方法进行肺癌诊疗终身模型的构建与开发，ZP202013，主持；

（9）胞外基质硬度通过细胞膜相关骨架结构调控肺鳞癌细胞迁移的机制研究，2021-YGJC-02，共同主持；

（10）基于人工智能与大数据的原发性肺癌智能专家辅助决策系统的开发与应用研究，19-112-4-090，主持；

（11）DUSP6与肺鳞癌铂类耐药的机制研究，20180550741，结题，主持；

（12）应用[18F]fluorodeoxyglucose(FDG) PET/CT指导局部晚期非小细胞肺癌精确放疗的研究，NCC2017A08，结题，主持；

最近5年发表文章

[1]Yu Wu,Yingqiu Song, Runze Wang, Tianlu Wang*, Molecular mechanisms of tumor  resistance to radiotherapy, Molecular Cancer.2023,22:96.(Q1, IF:37.3)

[2]Shuang Ma, Junfeng Wu, Zhihua Liu, Rong He, Yuechao Wang, Lianqing Liu, Tianlu Wang*, Wenxue Wang*, Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication, Journal of Pharmaceutical Analysis.13 March 2023.(Q1, IF:8.8)

[3]Weilin Zeng, Yingqiu Song, Runze Wang, Rong He,Tianlu Wang*, Neutrophil elastase: From mechanisms to therapeutic potential,Journal of Pharmaceutical Analysis.7 January 2023.(Q1,IF:14)

[4] Yingying Yuan, Bo Liu, Tianlu Wang*, Na Li, Zhengyao Zhang, Hangyu Zhang*, Electrochemical microfluidic paper-based analytical devices for tumor marker detection, TrAC Trends in Analytical Chemistry. 2022, 157:116816.（Q1，IF：14)

[5] Hongting Ma,... Tianlu Wang*, Mianqi Xue*, Nan Zhu*,Wood-derived flexible supercapacitors for anti-freezing green power sources,Journal of Materials Chemistry A. 2024,2050-7488. (Q2, IF:10.7)

[6]Yingying Yuan, Bo Liu, Hui Li, Mo Li , Yingqiu Song, Runze Wang, Tianlu Wang*, Hangyu Zhang*,  Flexible Wearable Sensors in Medical Monitoring, Biosensors. 2022, 12: 1069.（Q2，IF: 5.8）

[7] Jin G, Wang R, Jin Y, Song Y, Tianlu Wang*. From intramuscular to nasal: unleashing the potential of nasal spray vaccines against coronavirus disease 2019. Clin Transl Immunology. 2024;13(5):e1514. （Q2，IF: 5.8）

[8]Zhou C, Zhang X, Yan X, Xie H, Tan H, Song Y, Li M, Jin Y, Wang T*. Impact of lung adenocarcinoma subtypes on survival and timing of brain metastases. Front Oncol. 2024 Sep 3;14:1433505. （Q3, IF：3.5）

[9]Zhang X, Zeng W, Yan X, Wang Z, Xu K, Li M, Wang T*, Song Y. Association between smoking status and the prognosis of brain metastasis in patients with non-small cell lung cancer. Front Oncol. 2024 Sep 19;14:1403344. （Q3, IF：3.5）

[10]Wang Y, Song Y, Wang R, Wu Y, Li M, Xu K, He R, Wang Z, Li Q, Kong FS, Tianlu Wang*. Clinical factors and major pathological response after neoadjuvant chemoimmunotherapy in potentially resectable lung squamous cell carcinoma. Front Oncol. 2024 Apr 12;14:1265228. doi: 10.3389/fonc.2024.1265228. （Q3, IF：4.7）

[11] Li J, Zhang X, Wang Y, Jin Y, Song Y and Tianlu Wang*. Clinicopathological characteristics and prognosis of synchronous brain metastases from non-small cell lung cancer compared with metachronous brain metastases. Front Oncol. 2024 May; 14:1400792. doi: 10.3389/fonc.2024.1400792.（Q3, IF：4.7）

[12]Zhang X, Zeng W, Yan X, Wang Z, Xu K, Li M, Tianlu Wang*, Song Y*. Association between smoking status and the prognosis of brain metastasis in patients with non-small cell lung cancer. Front Oncol. 2024 Sep 19;14:1403344. doi: 10.3389/fonc.2024.1403344. （Q3, IF：4.7）

[13]Zhang X, Che X, Zhang S, Wang R, Li M, Jin Y, Tianlu Wang*, Song Y. Mesenchymal stem cell-derived extracellular vesicles for human diseases. Extracell Vesicles Circ Nucleic Acids 2024;5:64-82. https://dx.doi.org/10.20517/evcna.2023.4

[14] Chensen Liu, Yingqiu Song†, Runze Wang, Zheng Wang,  Rong He, Ke Xu, Chenyu Wang, Yu Wu,Ye Wang, Xiaofang Zang, Gaung Li, Tianlu Wang*, Thorax radiotherapy using 18F-positron emission tomography/computed tomography-guided precision radiotherapy is a prognostic factor for survival in patients with extracranial oligometastatic non-small cell lung cancer:A two-center propensity score-matched analysis, Front. Oncol. 2022,12:991378.（Q3，IF:5.8）

[15] Xiaofang Zhang,  Tianlu Wang†, Chenyu Wang, Yingqiu Song*, Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial, Trials. 2022, 23(1): 1-9.（Q4，IF:2.7）

[16] Nan Wang,  Yun Qiao, Yingqiu Song†, Zheng Wang, Xia Li, Chengsen Liu, Ye Wang, Yu Wu, Rong He, Chenyu Wang, Yangwu Ren, Guang Li, Tianlu Wang*, In 18F-positron emission tomography/computed tomography-guided precision radiotherapy for centra-lly located non-small cell lung cancer, tumor related atelectasis is a prognostic factor of survival: Bicentral Propensity Score Maching Analysis, Frontiers in Oncology. 2022;12:2234-943X. （Q3，IF: 5.8）

[17] Xiaofang Zhang, Sibo Zhang, Tianlu Wang*, How the mechanical microenvironment of stem cell growth affects their differentiation: a review. Stem Cell Res Ther. 2022,13:415.（Q2，IF: 8.1）

[18] Xiaofang Zhang, Donggang Xu, Tianlu Wang*, Research Progress in the Application of Exosomes in Immunotherapy, Front Immunol. 2022, 15(13):731516. （Q2，IF: 7.5）

[19] Siqi Zhang, Junwei Ye, Tianlu Wang, Guiling Ning, Dual Stimuli-Responsive smart fibrous membranes for efficient Photothermal/Photodynamic/Chemo-Ther-apy of Drug-Resistant bacterial infection,Chemical Engineering Journal. 2022, 432:27. （Q1，IF: 13.3）

[20] Shuang Ma, Xiaofang Zhang, Dan Dang, Wenxue Wang, Tianlu Wang*, Dynamic Characterization of Sin-gle Cells Based on Temporal Cellular Mechanical Properties, IEEE Transactions on Nanobioscience. 2023,22(1):19-27.. （Q3，IF: 3.2）

[21] Xiaofang Zhang, Tianlu Wang†, Xinyan Xiao,  Xia Li, Chen Yu Wang, Bo Huang, Lei He, Yingqiu Song*, Radiotherapy for head and neck tumours using an oral fixation and parameter acquisition device and TOMO technology: a randomised controlled study, BMJ open. 2021, 11(11): e052542.（Q3，IF: 2.7）

[22] Shuang Ma, Wenxue Wang, Yuechao Wang, Lianqing Liu, Tianlu Wang*, A New Method for Characteri-zation of Single Cell Using System Identification, 2021 IEEE International Conference on Nano-Micro Eng-ineered and Molecular Systems NEMS, 2021. (EI)

[23] Yingqiu Song†, Nan Wang, Yun Qiao, Lei He, Xia Li, Xiaofang Zhang, Qiankun Yang, Runze Wang, Rong He, Chenyu Wang, Yangwu Ren, Guang Li, Tianlu Wang*, Treatment patterns and survival after 18F-fuorodeoxyglucose positron emission tomography/com-puted tomography-guided local consolidation therapy for oligometastatic non-small cell lung cancer: a two center propensity score matched analysis, Journal of Cancer Research and Clinical Oncology. 2020, 146: 1021-1031. （Q3，IF: 3.3）

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