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发布时间：2019-03-11

论文类型：期刊论文

发表时间：2018-04-15

发表刊物：Carbohydrate polymers

收录刊物：PubMed、EI、SCIE

卷号：186

页面范围：82-90

ISSN号：1879-1344

关键字：Chitosan,Drug delivery,Hyaluronic acid,Hydrogel,Injectability

摘要：Hydrogels based on chitosan/hyaluronic acid/beta-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface of the hydrogels, which will be beneficial for tumor site-specific administration of drug. The mechanical strength, the gelation temperature, and the drug release behavior can be tuned by varying hyaluronic acid content. The mechanisms were characterized using dynamic mechanical analysis, Fourier transform infrared spectroscopy, scanning electron microscopy and fluorescence microscopy. The carboxyl group in hyaluronic acid can form the hydrogen bondings with the protonated amine in chitosan, which promotes the increase of mechanical strength of the hydrogels and depresses the initial burst release of drug from the hydrogel. Copyright © 2018 Elsevier Ltd. All rights reserved.