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论文类型：期刊论文

发表时间：2019-10-01

发表刊物：BIOMACROMOLECULES

收录刊物：PubMed、SCIE

卷号：20

期号：10

页面范围：3952-3968

ISSN号：1525-7797

摘要：A facile method in combination of "grafting from" and "end-functionalization" was developed for the synthesis of fluorescent highly branched poly(L-lactide)s (PLLA-COU) via ring opening polymerization (ROP) and esterification end-capping. These resulting PLLA-COU with four kinds of architectures, including linear, star, linear-comb, and star-comb structures, were subjected to characterization and application as fluorescent visible paclitaxel-loaded micro spheres. The mutual effects of architecture and end-groups on thermal and fluorescence properties, enzymatic degradation, and drug release behaviors were focused. Contrast to linear and star PLLA-COU, two comb-shaped analogues demonstrated higher fluorescence quantum yield, faster drug release, and lower enzymatic degradation rate. All the fluorescent microspheres could maintain fluorescence traceability. The fluorescent PLLA-COU displayed negligible toxicity and good biocompatibility. This work highlights that the fluorescent highly branched poly(L-lactide)s are properties-tailored and used as fluorescent visible drug delivery systems (DDS) for potential theranostic applications.