- COHESIVE FINITE ELEMENT SIMULATIONS OF CONTRACTION AND SHAPE EFFECTS ON CELL DE-ADHESION
- 点击次数：
- 论文类型： 期刊论文
- 发表时间： 2017-09-01
- 发表刊物： JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
- 收录刊物： Scopus、SCIE、EI
- 卷号： 17
- 期号： 6
- ISSN号： 0219-5194
- 关键字： Cell de-adhesion; cohesive interface model; finite element simulations; nonlinear fracture mechanics
- 摘要： Cohesive-interface-based finite element simulations were conducted to investigate the critical shear stress required for cell de-adhesion from extracellular substrates. The interface ligand-receptor bonds are modeled by a cohesive interface model with initial stiffness, interface strength, and fracture energy as the governing parameters. The ratio of the cell modulus to the interface stiffness defines a length scale. If this length is much less than the contact size, the de-adhesion process can be modeled by the linear elastic fracture mechanics, while the opposite limit leads to the concurrent sliding of the cell or, equivalently, debonding of all the interface ligand-receptor pairs. Since it generates additional shear-stress concentration along the interface, cell contraction generally reduces the critical de-adhesion stress. Cell de-adhesion is more prone to take place for three-dimensional irregular cell shapes because of the much easier failure in the anti-plane Mode III shear, as well as the additional stress concentration in these geometric irregularities.
