Reductive Metabolism of Nitroaromatic Compounds by Various Liver Microsomes
发布时间：2019-03-09
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- 论文类型：
- 期刊论文
- 发表时间：
- 2010-11-01
- 发表刊物：
- CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
- 收录刊物：
- Scopus、CSCD、ISTIC、SCIE
- 文献类型：
- J
- 卷号：
- 26
- 期号：
- 6
- 页面范围：
- 981-985
- ISSN号：
- 1005-9040
- 关键字：
- Liver microsome; Reduction; Nitroaromatic compound; Aromatic hydroxylamine
- 摘要：
- Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Similar with baker's yeast, the pig, rat and sheep liver microsomes exhibited high reactivity toward 4-nitro-1,2-dicyanbenzen(1a), while the cyprinoid liver microsomes were inefficient. Contrasted to compound la, monocyannitrobenzene(2a) was difficult to reduce by pig liver microsomes. In opposition to grape cells, pig liver microsomes exhibited activities toward some aromatic hydroxylamine compounds.
- 第一作者
- Wang Xing-yong
- 合写作者
- Li Feng,Qian Xu-hong,Ren Wei-min,Zhao Guo-quan,Cui Jing-nan
- 通讯作者
- Cui, JN (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China.