Indexed by:期刊论文

Date of Publication:2018-02-06

Journal:ANALYTICAL CHEMISTRY

Included Journals:SCIE、EI、PubMed

Volume:90

Issue:3

Page Number:2164-2169

ISSN No.:0003-2700

Abstract:Nitric oxide (NO) potentially plays a regulatory role in mitochondrial fusion and fission, which are vital to cell survival and implicated in health, disease, and aging. Molecular tools facilitating the study of the relationship between NO and mitochondrial dynamics are in need. We have recently developed a novel NO donor (NOD550). Upon photoactivation, NOD550 decomposes to release two NO molecules and a fluorophore. The NO release could be spatially mapped with subdiffraction resolution and with a temporal resolution of 10 s. Due to the preferential localization of NOD550 at mitochondria, morphology and dynamics of mitochondria could be monitored upon NO release from NOD550.