Indexed by: 期刊论文

Date of Publication: 2012-10-24

Journal: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Included Journals: SCIE、EI、PubMed、ESI高被引论文、Scopus

Document Type: J

Volume: 134

Issue: 42

Page Number: 17486-17489

ISSN No.: 0002-7863

Abstract: A lysosome-specific and two-photon fluorescent probe, Lyso-NINO, demonstrates high selectivity and sensitivity toward NO, lower cytotoxicity, and perfect lysosomal localization. With the aid of Lyso-NINO, the first capture of NO within lysosomes of macrophage cells has been achieved using both two-photon fluorescence microscopy and flow cytometry.