Indexed by:Journal Article

Date of Publication:2008-03-01

Journal:JOURNAL OF FLUORESCENCE

Included Journals:EI、SCIE

Volume:18

Issue:2

Page Number:591-597

ISSN:1053-0509

Key Words:nitro-fluorophore; sensor; hypoxic; tumor cell

Abstract:Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells, two series of hypoxic sensors containing 7H-Benzimidazole [2,1-a]benz[de]isoquinolin-7-one cores with nitro groups in different positions were designed, synthesized and evaluated. The target compounds exhibited significantly different fluorescence characteristics ( fluorescence enhancement or quenching). The strong fluorescences of some partially reduced compounds could be explained through the examination of their infrared spectra, which showed a restriction of the nitro-group vibration. These compounds exhibited significant hypoxic-oxic fluorescence differences not only in numerical values but also in their fluorescent imaging properties as reported for the first time.