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发布时间：2019-03-10

论文类型：期刊论文

发表时间：2008-03-01

发表刊物：JOURNAL OF FLUORESCENCE

收录刊物：EI、SCIE

卷号：18

期号：2

页面范围：591-597

ISSN号：1053-0509

关键字：nitro-fluorophore; sensor; hypoxic; tumor cell

摘要：Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells, two series of hypoxic sensors containing 7H-Benzimidazole [2,1-a]benz[de]isoquinolin-7-one cores with nitro groups in different positions were designed, synthesized and evaluated. The target compounds exhibited significantly different fluorescence characteristics ( fluorescence enhancement or quenching). The strong fluorescences of some partially reduced compounds could be explained through the examination of their infrared spectra, which showed a restriction of the nitro-group vibration. These compounds exhibited significant hypoxic-oxic fluorescence differences not only in numerical values but also in their fluorescent imaging properties as reported for the first time.