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论文类型： 期刊论文

发表时间： 2008-03-01

发表刊物： JOURNAL OF FLUORESCENCE

收录刊物： SCIE、EI

卷号： 18

期号： 2

页面范围： 591-597

ISSN号： 1053-0509

关键字： nitro-fluorophore; sensor; hypoxic; tumor cell

摘要： Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells, two series of hypoxic sensors containing 7H-Benzimidazole [2,1-a]benz[de]isoquinolin-7-one cores with nitro groups in different positions were designed, synthesized and evaluated. The target compounds exhibited significantly different fluorescence characteristics ( fluorescence enhancement or quenching). The strong fluorescences of some partially reduced compounds could be explained through the examination of their infrared spectra, which showed a restriction of the nitro-group vibration. These compounds exhibited significant hypoxic-oxic fluorescence differences not only in numerical values but also in their fluorescent imaging properties as reported for the first time.