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个人信息Personal Information
副教授
博士生导师
硕士生导师
性别：男
毕业院校：中国协和医科大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 微生物学. 微生物与生化药学
办公地点：辽宁省大连市高新园区凌工路2号大连理工大学西部校区生物工程学院309室
联系方式：辽宁省大连市高新园区凌工路2号大连理工大学生物工程学院
电子邮箱：yshdong@dlut.edu.cn
Killing the muscular larvae of Trichinella spiralis and the anti-fibrotic effect of the combination of Wortmannilatone F and recombinant G31P in a murine model of trichinellosis
点击次数：
论文类型：期刊论文
发表时间：2018-12-01
发表刊物：BIOMEDICINE & PHARMACOTHERAPY
收录刊物：PubMed、SCIE、Scopus
卷号：108
页面范围：934-940
ISSN号：0753-3322
关键字：Trichinella spiralis; Fibroblast; Angiogenesis; Wortmannilactone F; G31P
摘要：Although trichinosis is one of the global food-borne parasitic diseases and is considered an emerging/re-emerging disease that has been reported in 66 countries, the drugs for its prevention and treatment have not been thoroughly investigated. Wortmannilactone F (WF) has been reported as a blocker of the helminth mitochondria respiratory chain by inhibiting NADH-fumarate reductase in the mitochondrial inner membrane. CXCL8 (3-73) K11R/G31 P(G31 P) has been reported as a CXCL8 analogue that has the affinity to CXCR1 and CXCR2. Male BALB/c mice were orally fed with 150 infective Trichinella spiralis (T. spiralis) larvae. Then, T. spiralis-infected mice were treated with WF and G31 P. The number and morphological analysis of encapsulated T. spiralis, collagen fiber accumulation, and the expression of angiogenic factors were investigated. WF and G31 P dramatically decreased the numbers of encapsulation, decreased collagen fibers, and suppressed angiogenesis. These findings indicate that the combination of WF and G31 P is a potential therapeutic strategy of Trichinellosis.