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论文类型：期刊论文

发表时间：2017-07-01

发表刊物：Advances in experimental medicine and biology

收录刊物：PubMed

卷号：1038

页面范围：149-171

ISSN号：0065-2598

关键字：Drug resistance,Metabolism,Mitochondrial,Signaling pathway

摘要：Mitochondria are generally considered as a powerhouse in a cell where the majority of the cellular ATP and metabolite productions occur. Metabolic rewiring and reprogramming may be initiated and regulated by mitochondrial enzymes. The hypothesis that cellular metabolic rewiring and reprogramming processes may occur as cellular microenvironment is disturbed, resulting in alteration of cell phenotype, such as cancer cells resistant to therapeutics seems to be now acceptable. Cancer metabolic reprogramming regulated by mitochondrial enzymes is now one of the hallmarks of cancer. This chapter provides an overview of cancer metabolism and summarizes progress made in mitochondria-mediated metabolic regulation in cancer drug resistance.