Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2017-08-07

Journal: ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals: PubMed、EI、SCIE

Volume: 15

Issue: 29

Page Number: 6185-6193

ISSN: 1477-0520

Abstract: An expedient protocol for Cu-catalyzed C-H oxidation/diacylation of indoles with arylglyoxal hydrates to construct indolyl diketones is developed. This methodology exhibits the synthetic utility of the synthesis of an indole-alkaloid 1,2-di(1H-indol-3-yl) ethane-1,2-dione and offers a straightforward means to produce different indolyl nitrogen-containing heterocycles such as indolyl quinoxaline, indolyl hydantoin and indolyl imidazole in high yields. Preliminary mechanistic studies indicate that two proposed pathways are involved in this process.