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Indexed by:期刊论文

Date of Publication:2017-08-07

Journal:ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals:SCIE、EI、PubMed

Volume:15

Issue:29

Page Number:6185-6193

ISSN No.:1477-0520

Abstract:An expedient protocol for Cu-catalyzed C-H oxidation/diacylation of indoles with arylglyoxal hydrates to construct indolyl diketones is developed. This methodology exhibits the synthetic utility of the synthesis of an indole-alkaloid 1,2-di(1H-indol-3-yl) ethane-1,2-dione and offers a straightforward means to produce different indolyl nitrogen-containing heterocycles such as indolyl quinoxaline, indolyl hydantoin and indolyl imidazole in high yields. Preliminary mechanistic studies indicate that two proposed pathways are involved in this process.