Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-09-15

Journal: BIOSENSORS & BIOELECTRONICS

Included Journals: Scopus、PubMed、EI、SCIE

Volume: 83

Page Number: 267-273

ISSN: 0956-5663

Key Words: GO hydrogel; Aptamer; Fluorescent detection; Antibiotic; Oxytetracycline; Sulfadimethoxine

Abstract: A fluorescent sensing platform based on graphene oxide (GO) hydrogel was developed through a fast and facile gelation, immersion and fluorescence determination process, in which the adenosine and aptamer worked as the co-crosslinkers to connect the GO sheets and then form the three-dimensional (3D) macrostructures. The as-prepared hydrogel showed high mechanical strength and thermal stability. The optimal hydrogel had a linear response for oxytetracycline (OTC) of 25-1000 mu g/L and a limit of quantitation (LOQ) of 25 mu g/L. Moreover, together with the high affinity of the aptamer for its target, this assay exhibited excellent sensitivity and selectivity. According to its design principle, the as-designed hydrogel was also tested to possess the generic detection function for other molecules by simply replacing its recognition element, which is expected to lay a foundation to realize the assembly of functionalized hierarchical graphene-based materials for practical applications in analytical field. (C) 2016 Elsevier B.V. All rights reserved.