Indexed by:Journal Article

Date of Publication:2017-11-17

Journal:ORGANIC LETTERS

Included Journals:PubMed、SCIE

Volume:19

Issue:22

Page Number:6200-6203

ISSN:1523-7060

Abstract:A highly regioselective method to access 5-amido fully Substituted 1,2,3-triazoles by iridium-catalyzed-azide-ynamide cycloaddition under mild, air, aqueous, and bioorthogonal conditions is reported. The excellent regioselectivities may derive from, the strong coordination between the carbonyl Oxygen of ynamide and the pi-acidic iridium. Since the iridium ion is insensitive to oxygen/water and exhibits low cytotoxicity, it could catalyze this reaction in both organic and biological environments efficiently. Preparation in gram-scale and application in carbohydrates highlight this method.