Title of Paper:Iridium-catalyzed orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions

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Date of Publication:2020-12-29

Journal:GREEN CHEMISTRY

Volume:22

Issue:8

Page Number:2394-2398

ISSN No.:1463-9262

Abstract:An orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions has been developed. This simple and practical approach is environment-friendly and compatible with oxygen/water and various complex biological media. It features excellent regioselectivities and chemoselectivities, high yields, good biocompatibility and bioorthogonality. Its applications in the synthesis of carbohydrates and trigger-responsive nanoparticles are further highlights of this aqueous transformation.