Title of Paper:Palladium-Catalyzed Regioselective and Diastereoselective C-Glycosylation by Allyl-Allyl Coupling

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Date of Publication:2021-03-13

Journal:ADVANCED SYNTHESIS & CATALYSIS

Volume:363

Issue:3

Page Number:846-850

ISSN No.:1615-4150

Key Words:C-glycosylation; Allyl-allyl coupling; Pd-π -allyl intermediate; Achmatowicz rearrangement products; Methylcoumarins

Abstract:A Pd-catalyzed C-glycosylation reaction was developed by allyl-allyl coupling process using Achmatowicz rearrangement products as donors and methylcoumarins as acceptors under mild conditions. This method featured regio- and diastereoselectivities, stereodivergent synthesis of C-glycosides. The glycosyl donors with controlled stereodiversity and glycosyl acceptors with fluorescent performace further highlighted this methodology.